guide strand造句
例句與造句
- Each siRNA is unwound into two single-stranded RNAs ( ssRNAs ), the passenger strand and the guide strand.
- The passenger strand is degraded and the guide strand is incorporated into the RNA-induced silencing complex ( RISC ).
- The dsRNA is then separated into two single-stranded RNAs ( ssRNA )-the passenger strand and the guide strand.
- Consequently, the passenger strand is degraded, while the guide strand is incorporated into the RNA-induced silencing complex ( RISC ).
- But only one of the two single-stranded RNA here will be utilized to base pair with target mRNA . It is known as the guide strand, incorporated into the Argonaute protein and leads gene silencing.
- It's difficult to find guide strand in a sentence. 用guide strand造句挺難的
- The most well-studied outcome of the RNAi is post-transcriptional gene silencing, which occurs when the guide strand pairs with a complementary sequence in a messenger RNA molecule and induces cleavage by Argonaute, that lies in the core of RISC.
- The most well-studied outcome is post-transcriptional gene silencing, which occurs when the guide strand pairs with a complementary sequence in a messenger RNA molecule and induces cleavage by Argonaute 2 ( Ago2 ), the catalytic component of the RISC complex.
- Argonautes are needed for miRNA-induced silencing and contain two conserved RNA binding domains : a PAZ domain that can bind the single stranded 3 end of the mature miRNA and a ribonuclease-H and functions to interact with the 5 end of the guide strand.
- Analysis of the inhibitory effect of mismatches in either the 5 or 3 end of the guide strand has demonstrated that the 5 end of the guide strand is likely responsible for matching and binding the target mRNA, while the 3 end is responsible for physically arranging target mRNA into a cleavage-favorable RISC region.
- Analysis of the inhibitory effect of mismatches in either the 5 or 3 end of the guide strand has demonstrated that the 5 end of the guide strand is likely responsible for matching and binding the target mRNA, while the 3 end is responsible for physically arranging target mRNA into a cleavage-favorable RISC region.
- In a manner similar to siRNA duplexes, one of the two strands, the " passenger miRNA " ( miR-155 * ), is released and degraded while the other strand, designated the " guide strand " or " mature miRNA " ( miR-155 ), is retained within the RISC.